Non-randomness distribution of micro-RNAs on human chromosomes
نویسندگان
چکیده
منابع مشابه
Long non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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The advent of ultra-high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16-40 nucleotides in size. We will highlight how some ...
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Two small temporally regulated RNAs (stRNAs)* of approximately 22 nucleotides regulate timing of gene expression during development of the nematode C. elegans. This regulation occurs at a posttranscriptional, presumably translational, level and is distinct from RNA interference (RNAi). One of the two stRNAs, let-7, as well as its target gene, lin-41, are highly conserved even in humans, suggest...
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6 Litman, R. M., and A. B. Pardee, Nature, 178, 529 (1957). 7 Dunn, D. B., and J. D. Smith, Nature, 174, 305 (1954). 8 Benzer, S., these PROCEEDINGS, 41, 344 (1955). 9 Benzer, S., and E. Freese, these PROCEEDINGS, 44, 112 (1958). 10 Freese, E., these PROCEEDINGS, 45, 622 (1959). 11 S6chaud, J., and E. Kellenberger, Ann. Inst. Pasteur, 90, 102 (1956). 12 Garen, A., personal communication. 13 Uch...
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Background Why does a tumor start where it does within an organ? Location is traditionally viewed as a random event, yet the statistics of the location of tumors argues against this being a random occurrence. There are numerous examples including that of breast cancer. More than half of invasive breast cancer tumors start in the upper outer quadrant of the breast near the armpit, even though it...
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2019
ISSN: 2090-2441
DOI: 10.1186/s43042-019-0041-2